A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
نویسندگان
چکیده
منابع مشابه
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
Genetically engineered mouse models (GEMMs) have dramatically improved our understanding of tumor evolution and therapeutic resistance. However, sequential genetic manipulation of gene expression and targeting of the host is almost impossible using conventional Cre-loxP–based models. We have developed an inducible dual-recombinase system by combining flippase-FRT (Flp-FRT) and Cre-loxP recombin...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2014
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm.3646